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eclipse ti2 inverted widefield microscope  (Nikon)

 
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    Structured Review

    Nikon eclipse ti2 inverted widefield microscope
    (A) Venn diagram highlighting overlapping biological process GO: terms derived from MOFA weighted transcripts for CCDC88A::ALK (green) and CLIP1::ROS1 (berry), respectively; right: bar plot view on overlapping GO:terms from (A), x-axis: −log10 p-value based on toppgene analysis; y-axis: identified GO:terms, bold: pathways involved in motility; green: CCDC88A::ALK, berry: CLIP1::ROS1. (B) <t>Widefield</t> immunofluorescence showcasing overlapping staining of CCDC::ALK or CLIP1::ROS1, respectively, with microtubules; EV: empty vector, KD: kinase dead control; ΔTUB: abrogated microtubule interaction domain; β-TUB: marker for microtubules; scalebar: 10µm. (C) Drug titration curves highlighting dose dependent effects of 72h treatment with STAT3i (Stattic) on iNHA models, dark green: CCDC88A::ALK, light green: CCDC88A::ALK KD , berry: CLIP1::ROS1; light berry: CLIP1::ROS1 KD , y-axis: log 10 drug concentrations, y-axis: survival normalized to DMSO control; dashed line: 50% survival; error bars: SD of 3 biological replicates.
    Eclipse Ti2 Inverted Widefield Microscope, supplied by Nikon, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/eclipse ti2 inverted widefield microscope/product/Nikon
    Average 90 stars, based on 1 article reviews
    eclipse ti2 inverted widefield microscope - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation"

    Article Title: Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation

    Journal: bioRxiv

    doi: 10.1101/2025.05.27.656302

    (A) Venn diagram highlighting overlapping biological process GO: terms derived from MOFA weighted transcripts for CCDC88A::ALK (green) and CLIP1::ROS1 (berry), respectively; right: bar plot view on overlapping GO:terms from (A), x-axis: −log10 p-value based on toppgene analysis; y-axis: identified GO:terms, bold: pathways involved in motility; green: CCDC88A::ALK, berry: CLIP1::ROS1. (B) Widefield immunofluorescence showcasing overlapping staining of CCDC::ALK or CLIP1::ROS1, respectively, with microtubules; EV: empty vector, KD: kinase dead control; ΔTUB: abrogated microtubule interaction domain; β-TUB: marker for microtubules; scalebar: 10µm. (C) Drug titration curves highlighting dose dependent effects of 72h treatment with STAT3i (Stattic) on iNHA models, dark green: CCDC88A::ALK, light green: CCDC88A::ALK KD , berry: CLIP1::ROS1; light berry: CLIP1::ROS1 KD , y-axis: log 10 drug concentrations, y-axis: survival normalized to DMSO control; dashed line: 50% survival; error bars: SD of 3 biological replicates.
    Figure Legend Snippet: (A) Venn diagram highlighting overlapping biological process GO: terms derived from MOFA weighted transcripts for CCDC88A::ALK (green) and CLIP1::ROS1 (berry), respectively; right: bar plot view on overlapping GO:terms from (A), x-axis: −log10 p-value based on toppgene analysis; y-axis: identified GO:terms, bold: pathways involved in motility; green: CCDC88A::ALK, berry: CLIP1::ROS1. (B) Widefield immunofluorescence showcasing overlapping staining of CCDC::ALK or CLIP1::ROS1, respectively, with microtubules; EV: empty vector, KD: kinase dead control; ΔTUB: abrogated microtubule interaction domain; β-TUB: marker for microtubules; scalebar: 10µm. (C) Drug titration curves highlighting dose dependent effects of 72h treatment with STAT3i (Stattic) on iNHA models, dark green: CCDC88A::ALK, light green: CCDC88A::ALK KD , berry: CLIP1::ROS1; light berry: CLIP1::ROS1 KD , y-axis: log 10 drug concentrations, y-axis: survival normalized to DMSO control; dashed line: 50% survival; error bars: SD of 3 biological replicates.

    Techniques Used: Derivative Assay, Immunofluorescence, Staining, Plasmid Preparation, Control, Marker, Titration



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    Image Search Results


    (A) Venn diagram highlighting overlapping biological process GO: terms derived from MOFA weighted transcripts for CCDC88A::ALK (green) and CLIP1::ROS1 (berry), respectively; right: bar plot view on overlapping GO:terms from (A), x-axis: −log10 p-value based on toppgene analysis; y-axis: identified GO:terms, bold: pathways involved in motility; green: CCDC88A::ALK, berry: CLIP1::ROS1. (B) Widefield immunofluorescence showcasing overlapping staining of CCDC::ALK or CLIP1::ROS1, respectively, with microtubules; EV: empty vector, KD: kinase dead control; ΔTUB: abrogated microtubule interaction domain; β-TUB: marker for microtubules; scalebar: 10µm. (C) Drug titration curves highlighting dose dependent effects of 72h treatment with STAT3i (Stattic) on iNHA models, dark green: CCDC88A::ALK, light green: CCDC88A::ALK KD , berry: CLIP1::ROS1; light berry: CLIP1::ROS1 KD , y-axis: log 10 drug concentrations, y-axis: survival normalized to DMSO control; dashed line: 50% survival; error bars: SD of 3 biological replicates.

    Journal: bioRxiv

    Article Title: Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation

    doi: 10.1101/2025.05.27.656302

    Figure Lengend Snippet: (A) Venn diagram highlighting overlapping biological process GO: terms derived from MOFA weighted transcripts for CCDC88A::ALK (green) and CLIP1::ROS1 (berry), respectively; right: bar plot view on overlapping GO:terms from (A), x-axis: −log10 p-value based on toppgene analysis; y-axis: identified GO:terms, bold: pathways involved in motility; green: CCDC88A::ALK, berry: CLIP1::ROS1. (B) Widefield immunofluorescence showcasing overlapping staining of CCDC::ALK or CLIP1::ROS1, respectively, with microtubules; EV: empty vector, KD: kinase dead control; ΔTUB: abrogated microtubule interaction domain; β-TUB: marker for microtubules; scalebar: 10µm. (C) Drug titration curves highlighting dose dependent effects of 72h treatment with STAT3i (Stattic) on iNHA models, dark green: CCDC88A::ALK, light green: CCDC88A::ALK KD , berry: CLIP1::ROS1; light berry: CLIP1::ROS1 KD , y-axis: log 10 drug concentrations, y-axis: survival normalized to DMSO control; dashed line: 50% survival; error bars: SD of 3 biological replicates.

    Article Snippet: Live-cell imaging was conducted on a Nikon ECLIPSE Ti2 inverted widefield microscope, capturing images every 6 minutes for 12 hours at 10× magnification.

    Techniques: Derivative Assay, Immunofluorescence, Staining, Plasmid Preparation, Control, Marker, Titration